再灌注损伤挽救激酶信号通路在心肌再灌注损伤保护中的研究进展

被引：10

作者：

吕磊

江时森

机构：

[1] 南京军区南京总医院(南京大学医学院临床学院)心血管内科

来源：

医学研究生学报 | 2010年 / 23卷 / 12期

关键词：

再灌注损伤挽救激酶信号通路; 磷脂酰肌醇-3激酶-蛋白激酶B; 信号调节蛋白激酶1/2; 心肌保护;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

再灌注损伤挽救激酶(reperfusion injury salvage kinase,RISK)信号通路是指一组促存活蛋白激酶,主要包括磷脂酰肌醇-3激酶(phosphatidylinositol-3-OHkinase,PI3K)-蛋白激酶B(Akt)和细胞外信号调节蛋白激酶1/2(extra-cellular sig-nal-regulated protein kinase 1/2,Erk1/2),心肌再灌注时被激活,有强大的心脏保护作用。机械干预(如缺血预适应和缺血后处理)和药物干预(如他汀,腺苷,心房钠尿肽等)均能激活RISK信号通路,使心肌梗死面积减少最多达50%。RISK信号通路是近年来研究较多的再灌注时干预的靶点,具有良好的应用前景。文中就RISK信号通路的定义、下游效应器以及作用于RISK信号通路的各种干预方法做一综述。

引用

页码：1309 / 1313

页数：5

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