铁代谢与肿瘤发生关系的研究进展

被引:2
作者
李志伟
曹霞
王鹏飞
机构
[1] 昆明医科大学第二附属医院中心实验室
关键词
铁代谢; 肿瘤; 铁螯合剂; 抗癌作用;
D O I
暂无
中图分类号
R730.231 [肿瘤病因学、发生学];
学科分类号
摘要
铁元素是生命活动的重要参与者,不仅参与细胞的氧化磷酸化过程、DNA合成及复制活动,还通过低氧诱导因子调控多个肿瘤发生相关基因。细胞癌变过程中改变了自身的铁代谢方式,使癌细胞成为铁元素的消耗大户。其中,铁的获取,外排,存储和调控在癌细胞中皆是紊乱的。因此,铁元素对肿瘤的生长,生存及转移具有重大潜在意义。文章综述了铁元素在癌细胞中的改变与肿瘤发生的关系以及目前铁螯合剂抑癌作用在临床运用中存在的问题,以肿瘤铁代谢作为治疗靶标可能为肿瘤的预后和治疗提供新思路。
引用
收藏
页码:998 / 1003
页数:6
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共 22 条
  • [1] 线粒体铁代谢与人类疾病的基础研究
    李宽钰
    [J]. 医学研究生学报, 2016, 29 (01) : 24 - 28
  • [2] p53在乳腺癌中的表达意义及5-氮杂脱氧胞苷对p53的调控作用
    赖静
    顾军
    许晶
    吴波
    张文文
    聂伟伟
    宋伟
    汪泽兴
    黄桂春
    管晓翔
    [J]. 医学研究生学报, 2014, (06) : 573 - 576
  • [3] Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
    Schito, Luana
    Semenza, Gregg L.
    [J]. TRENDS IN CANCER, 2016, 2 (12): : 758 - 770
  • [4] Oxidative stress and altered lipid metabolism in Friedreich ataxia.[J].Jordi Tamarit;Èlia Obis;Joaquim Ros.Free Radical Biology and Medicine.2016,
  • [5] Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.[J].Seung Min Jeong;Sunsook Hwang;Rho Hyun Seong.Biochemical and Biophysical Research Communicatio.2016,
  • [6] The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis.[J].Jia Shen;Xiangpeng Sheng;ZeNan Chang;Qian Wu;Dong Xie;Fudi Wang;Ronggui Hu.Molecular & Cellular Oncology.2016, 1
  • [7] Disordered hepcidin–ferroportin signaling promotes breast cancer growth.[J].Shuping Zhang;Yue Chen;Wenli Guo;Lin Yuan;Daoqiang Zhang;Yong Xu;Elizabeta Nemeth;Tomas Ganz;Sijin Liu.Cellular Signalling.2014, 11
  • [8] Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications.[J].Rongrong Jin;Bingbing Lin;Danyang Li;Hua Ai.Current Opinion in Pharmacology.2014,
  • [9] Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses
    Yoon, Haejin
    Shin, Seung-Hyun
    Shin, Dong Hoon
    Chun, Yang-Sook
    Park, Jong-Wan
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 444 (01) : 36 - 43
  • [10] p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron
    Shimizu, Rina
    Nguyen Ngoc Lan
    Tran Tien Tai
    Adachi, Yuka
    Kawazoe, Asako
    Mu, Anfeng
    Taketani, Shigeru
    [J]. GENE, 2014, 551 (01) : 79 - 85