中性粒细胞弹性蛋白酶在脑损伤中的作用机制

被引：17

作者：

凌海平

杭春华

机构：

[1] 南方医科大学南京临床医学院(南京军区南京总医院)神经外科

来源：

医学研究生学报 | 2013年 / 26卷 / 01期

关键词：

中性粒细胞弹性蛋白酶; 脑损伤; 血脑屏障; 凋亡;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

炎症损伤在脑损伤中的重要作用逐渐受到重视。中性粒细胞弹性蛋白酶(neutrophil elastase,NE)是重要的炎症介质,可通过极强的蛋白水解作用参与脑损伤后的血脑屏障破坏,促进炎症细胞浸润,并与神经元的凋亡有一定的相关性。

引用

页码：73 / 76

页数：4

共 15 条

[1]

Neutrophil elastase and neurovascular injury following focal stroke and reperfusion [J].

Stowe, Ann M. ;

Adair-Kirk, Tracy L. ;

Gonzales, Ernesto R. ;

Perez, Ronald S. ;

Shah, Aarti R. ;

Park, Tae S. ;

Gidday, Jeffrey M. .

NEUROBIOLOGY OF DISEASE, 2009, 35 (01) :82-90

[2]

Neutrophil elastase inhibitor attenuates hippocampal neuronal damage after transient forebrain ischemia in rats.[J].Hiroaki Matayoshi;Takao Hirata;Satoshi Yamashita;Kazuyoshi Ishida;Yoichi Mizukami;Toshikazu Gondo;Mishiya Matsumoto;Takefumi Sakabe.Brain Research.2009,

[3]

Neutrophil elastase activity compensates for a genetic lack of matrix metalloproteinase-9 (MMP-9) in leukocyte infiltration in a model of experimental peritonitis [J].

Kolaczkowska, Elzbieta ;

Grzybek, Weronika ;

van Rooijen, Nico ;

Piccard, Helene ;

Plytycz, Barbara ;

Arnold, Bernd ;

Opdenakker, Ghislain .

JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 85 (03) :374-381

[4]

ONO-5046 attenuation of delayed motor neuron death and effect on the induction of brain-derived neurotrophic factor; phosphorylated extracellular signal–regulated kinase; and caspase3 after spinal cord ischemia in rabbits.[J].Takashi Yamauchi;Yoshiki Sawa;Masahiro Sakurai;Takano Hiroshi;Goro Matsumiya;Koji Abe;Hikaru Matsuda.The Journal of Thoracic and Cardiovascular Surgery.2006, 3

[5]

ICAM-1 signal transduction in cells stimulated with neutrophil elastase [J].

Ishihara, Kohjiroh ;

Yamaguchi, Yasuo ;

Uchino, Shinichiro ;

Furuhashi, Takashi ;

Yamada, Shinwa ;

Kihara, Shinichi ;

Mori, Katsutaka ;

Ogawa, Michio .

DIGESTIVE DISEASES AND SCIENCES, 2006, 51 (11) :2102-2112

[6]

Neutrophil granules and secretory vesicles in inflammation [J].

Faurschou, M ;

Borregaard, N .

MICROBES AND INFECTION, 2003, 5 (14) :1317-1327

[7]

Survival and death-promoting events after transient spinal cord ischemia in rabbits: Induction of Akt and caspase3 in motor neurons [J].

Sakurai, M ;

Nagata, T ;

Abe, K ;

Horinouchi, T ;

Itoyama, Y ;

Tabayashi, K .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2003, 125 (02) :370-377

[8]

Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.[J].James M Devaney;Catherine M Greene;Clifford C Taggart;Tomás P Carroll;Shane J O’Neill;Noel G McElvaney.FEBS Letters.2003, 1

[9]

A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats [J].

Tonai, T ;

Shiba, K ;

Taketani, Y ;

Ohmoto, Y ;

Murata, K ;

Muraguchi, M ;

Ohsaki, H ;

Takeda, E ;

Nishisho, T .

JOURNAL OF NEUROCHEMISTRY, 2001, 78 (05) :1064-1072

[10]

Neutral proteases and disruption of the blood–brain barrier in rat.[J].Diane Armao;Mario Kornfeld;Edward Y. Estrada;Mark Grossetete;Gary A. Rosenberg.Brain Research.1997, 2

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