腰椎后外侧融合动物模型及邻近节段的病理变化

被引:16
作者
许斌 [1 ]
陈跃先 [1 ]
赵建宁 [1 ]
王与荣 [1 ]
吴波 [2 ]
机构
[1] 南京军区南京总医院
[2] 南京军区南京总医院病理科
关键词
腰椎; 脊柱融合; 邻近节段退变;
D O I
暂无
中图分类号
R681.5 [脊柱及背疾病]; R-332 [医用实验动物学];
学科分类号
100220 [骨科学]; 100402 [劳动卫生与环境卫生学];
摘要
目的:文献报道脊柱融合对邻近节段退变的影响均集中在生物力学、影像学方面,缺少相关的实验研究,本文通过建立腰椎后外侧融合动物模型,观察其对邻近节段椎间盘退变的影响。建立腰椎后外侧融合动物模型,观察其对邻近节段椎间盘退变的影响。方法:后正中暴露兔腰4~6椎板及横突,用0.8mm钢丝行双侧腰4~6横突间8字内固定,然后用骨水泥包绕横突及钢丝。观察术后3个月、6个月时邻近节段椎间盘的病理改变。结果:组织学观察显示术后3个月时实验组L3-4椎间盘即有退变性改变,退变程度按Miyamoto分级为2级,至术后6个月时则退变更加明显,达3级。结论:腰椎后外侧融合会引起邻近节段椎间盘的退变加速。
引用
收藏
页码:249 / 251+338 +338
页数:4
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