瑞芬太尼复合麻醉患者术后急性阿片类药物耐受的发生

被引：91

作者：

王庚

吴新民

机构：

[1] 北京大学第一医院麻醉科

来源：

中华麻醉学杂志 | 2007年 / 05期

关键词：

哌啶类; 镇痛药,阿片类; 药物耐受性;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

1002 ; 100210 ;

摘要：

目的评价瑞芬太尼复合麻醉患者术后急性阿片类药物耐受的发生情况。方法60例择期手术患者随机分为3组(n=20),吸入麻醉组吸入1.3 MAC异氟醚和氧化亚氮维持麻醉;静脉麻醉组靶控输注(TCI)异丙酚(血浆靶浓度3μg/ml)、瑞芬太尼(血浆靶浓度4 ng/ml)维持麻醉;复合麻醉组吸入0.8 MAC异氟醚和氧化亚氮及TCI瑞芬太尼(血浆靶浓度2 ng/ml)维持麻醉。观察术后早期恢复阶段(30 min)患者的疼痛评分及吗啡用量。结果静脉麻醉组和复合麻醉组在术后早期恢复阶段的疼痛评分及吗啡用量均高于吸入麻醉组(P<0.05),但2组间比较差异无统计学意义(P> 0.05)。结论患者瑞芬太尼复合TCI异丙酚或复合吸入异氟醚麻醉均可导致急性阿片类药物耐受的发生。

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