缺血性脑卒中动物模型研究进展

被引：18

作者：

王晋晨

熊晓星

机构：

[1] 武汉大学人民医院神经外科

来源：

医学综述 | 2020年 / 26卷 / 10期

关键词：

缺血性脑卒中; 线栓模型; 开颅电凝模型; 内皮素-1模型; 光化学栓塞模型; 凝块栓子栓塞模型;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）]; R-332 [医用实验动物学];

学科分类号：

100204 [神经病学]; 100402 [劳动卫生与环境卫生学];

摘要：

缺血性脑卒中是由大脑暂时性或永久性血管闭塞所引起的损伤。梗死体积和神经系统功能缺失的严重程度取决于多种因素,如有无侧支循环建立和足够的血压保持灌注,梗死的病因及部位,年龄、性别、遗传背景,是否有并发症,是否经过药物治疗等。因此,脑卒中是一种非常复杂的病变过程,建立脑卒中模型显得十分重要,通过建立模型可以实现对单一影响因素的研究。常用的模型有线栓模型、开颅电凝模型、内皮素-1模型、光化学栓塞模型、凝块栓子模型等。未来,深入研究各脑卒中模型的优缺点,将为脑卒中研究者提供参考。

引用

页码：1881 / 1886+1892 +1892

页数：7

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