脓毒症发病机制最新认识

被引：215

作者：

姚咏明

张艳敏

机构：

[1] 解放军总医院第一附属医院创伤研究中心

来源：

医学研究生学报 | 2017年 / 30卷 / 07期

关键词：

脓毒症; 炎症反应; 免疫紊乱; 凝血异常;

D O I：

暂无

中图分类号：

R459.7 [急症、急救处理];

学科分类号：

100231 [临床病理学];

摘要：

脓毒症及脓毒性休克是ICU常见的危重症,其病死率高且严重影响患者的生活质量。脓毒症发病机制复杂,涉及机体多个器官功能改变,对其发病本质的探索一直是全球的研究热点。文中将总结分析近年来脓毒症发病机制的研究进展,分别从炎症反应失衡、免疫功能紊乱、凝血异常以及神经-内分泌-免疫网络、线粒体损伤、内质网应激、细胞自噬、基因多态性等方面分析脓毒症的病理生理过程,为其临床防治提供理论依据。

引用

页码：678 / 683

页数：6

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