高同型半胱氨酸血症致血管内皮损伤与早期动脉粥样硬化

被引：34

作者：

鲍晓梅

陆国平

机构：

[1] 上海交通大学医学院附属瑞金医院心血管内科

来源：

医学综述 | 2009年 / 15卷 / 02期

关键词：

高同型半胱氨酸血症; 血管内皮损伤; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R589 [代谢病]; R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

高同型半胱氨酸血症是动脉粥样硬化性心血管疾病的独立危险因素。血管内皮细胞不仅是血管内壁的屏障,而且可通过合成及分泌各种活性因子,发挥抗炎、抗凝、抗血栓形成,抑制血管平滑肌细胞生长,调节血管张力的作用。而同型半胱氨酸通过氧化应激、低甲基化反应、蛋白质同型半胱氨酸化、内皮祖细胞功能障碍等机制对内皮细胞结构功能的损伤则是引发早期动脉粥样硬化的关键。

引用

页码：191 / 193

页数：3

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