壳聚糖对温敏性原位凝胶基质体外流变学特性的影响附视频

被引:21
作者
徐玉红 [1 ]
李东 [2 ]
王蔓琳 [1 ]
李玉珍 [1 ]
何文 [3 ]
机构
[1] 广东省深圳市第四人民医院药剂科
[2] 暨南大学第二临床医学院、深圳市人民医院临床药学研究室
[3] 武汉大学人民医院药学部
关键词
壳聚糖; 泊洛沙姆; 原位凝胶; 流变学性质; 体外;
D O I
暂无
中图分类号
R94 [药剂学];
学科分类号
100702 [药剂学];
摘要
目的考察壳聚糖对泊洛沙姆为基质的温敏性原位凝胶流变学特性的影响,为两者的配伍使用提供依据。方法将不同质量分数的壳聚糖与泊洛沙姆溶液(P407和P188的质量分数均为15%)制备成原位凝胶,测定原位凝胶的体外胶凝温度、胶凝强度和生物黏附力。结果当壳聚糖的质量分数从0上升至0.6%时,基质的胶凝强度和生物黏附力均逐渐升高,胶凝温度无明显变化。结论壳聚糖可改善以泊洛沙姆为基质的原位凝胶的流变学性质。
引用
收藏
页码:4 / 5
页数:2
相关论文
共 8 条
[1]
In situ-forming hydrogels—review of temperature-sensitive systems[J] Eve Ruel-Gariépy;Jean-Christophe Leroux European Journal of Pharmaceutics and Biopharmaceutics 2004,
[2]
Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions[J] Jung Yun Chang;Yu-Kyoung Oh;Han-gon Choi;Yang Bae Kim;Chong-Kook Kim International Journal of Pharmaceutics 2002,
[3]
Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis[J] Jung Yun Chang;Yu-Kyoung Oh;Hak Soo Kong;Eun Jung Kim;Dong Deuk Jang;Ki Taek Nam;Chong-Kook Kim Journal of Controlled Release 2002,
[4]
Effect of sodium chloride on the gelation temperature; gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium[J] Chul Soon Yong;Jin Suck Choi;Qi-Zhe Quan;Jong-Dal Rhee;Chong-Kook Kim;Soo-Jeong Lim;Kyung-Mi Kim;Phil-Soo Oh;Han-Gon Choi International Journal of Pharmaceutics 2001,
[5]
Effect of additives on the physicochemical properties of liquid suppository bases[J] Han-Gon Choi;Mi-Kyung Lee;Moon-Hee Kim;Chong-Kook Kim International Journal of Pharmaceutics 1999,
[6]
Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention[J] O. Felt;P. Furrer;J.M. Mayer;B. Plazonnet;P. Buri;R. Gurny International Journal of Pharmaceutics 1999,
[7]
Increased bioavailability of propranolol in rats by retaining thermally gelling liquid suppositories in the rectum[J] Jei-Man Ryu;Suk-Jae Chung;Min-Hwa Lee;Chong-Kook Kim;Chang-Koo Shim Journal of Controlled Release 1999,
[8]
Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository[J] Han-Gon Choi;Jae-Hee Jung;Jei-Man Ryu;Sung-June Yoon;Yu-Kyoung Oh;Chong-Kook Kim International Journal of Pharmaceutics 1998,