NADPH氧化酶与糖尿病慢性并发症的关系

被引：2

作者：

邱轩

刘宽芝

机构：

[1] 河北医科大学第三医院内分泌一科

来源：

医学综述 | 2013年 / 19卷 / 20期

关键词：

还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶; 氧化应激; 糖尿病慢性并发症;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶是一种广泛存在的过氧化物酶,其催化产物活性氧参与了机体细胞防御、分化、增殖、凋亡等生理过程。然而在病理状态下,NADPH氧化酶过度激活、参与蛋白激酶C(PKC)调节、晚期糖基化终末产物(AGEs)通路、多元醇途径、己糖胺途径等进程,造成血管内皮损伤、血流供应减少及神经组织破坏等,促使糖尿病慢性并发症的形成和发展。因此,抗氧化应激治疗在糖尿病慢性并发症防治过程中具有重要作用。

引用

页码：3760 / 3762

页数：3

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