脑血管危险因素与Alzheimer病

被引:29
作者
于宝成
王玉敏
魏士贤
机构
[1] 解放军白求恩国际和平医院干部病房二科
[2] 解放军白求恩国际和平医院干部病房二科 石家庄
[3] 石家庄
关键词
脑血管; 危险因素; Alzheimer病;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)]; R749.1 [脑器质性精神障碍];
学科分类号
1002 ; 100205 ;
摘要
Alzheimer病(AD)是老年期痴呆的一个主要类型,有关AD危险因素的研究已有很多报道,比较一致的认识是,家族史、高龄、女性和雌激素水平的下降可使患AD的危险性增加。最近大量的研究发现,脑血管危险因素,如高血压、ApoE ε4等位基因、冠状动脉疾病、高胆固醇血症、高同型半胱氨酸血症和吸烟等也是AD的危险因素。
引用
收藏
页码:374 / 376
页数:3
相关论文
共 11 条
[1]   Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia [J].
Meyer, JS ;
Rauch, G ;
Rauch, RA ;
Haque, A .
NEUROBIOLOGY OF AGING, 2000, 21 (02) :161-169
[2]  
Midlife blood pressure and neuritic plaques; neurofibrillary tangles; and brain weight at death: the HAAS ☆.[J].H Petrovitch;L.R White;G Izmirilian;G.W Ross;R.J Havlik;W Markesbery;J Nelson;D.G Davis;J Hardman;D.J Foley;L.J Launer.Neurobiology of Aging.2000, 1
[3]  
Cerebral Hypoperfusion; Capillary Degeneration; and Development of Alzheimer Disease.[J].Jack C de la Torre.Alzheimer Disease and Associated Disorders.2000, 1 Su
[4]   Diabetes mellitus and the risk of dementia - The Rotterdam Study [J].
Ott, A ;
Stolk, RP ;
van Harskamp, F ;
Pols, HAP ;
Hofman, A ;
Breteler, MMB .
NEUROLOGY, 1999, 53 (09) :1937-1942
[5]   Midlife cardiovascular risk factors and brain morphology in identical older male twins [J].
Carmelli, D ;
Swan, GE ;
Reed, T ;
Wolf, PA ;
Miller, BL ;
DeCarli, C .
NEUROLOGY, 1999, 52 (06) :1119-1124
[6]   Cerebral amyloid angiopathy in Alzheimer disease is associated with apolipoprotein E4 and cortical neuron loss [J].
Zarow, C ;
Zaias, B ;
Lyness, SA ;
Chui, H .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1999, 13 (01) :1-8
[7]   Association of midlife blood pressure to late-life cognitive decline and brain morphology [J].
Swan, GE ;
DeCarli, C ;
Miller, BL ;
Reed, T ;
Wolf, PA ;
Jack, LM ;
Carmelli, D .
NEUROLOGY, 1998, 51 (04) :986-993
[8]   Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study [J].
Ott, A ;
Slooter, AJC ;
Hofman, A ;
van Harskamp, F ;
Witteman, JCM ;
Van Broeckhoven, C ;
van Duijn, CM ;
Breteler, MMB .
LANCET, 1998, 351 (9119) :1840-1843
[9]   15-year longitudinal study of blood pressure and dementia [J].
Skoog, I ;
Lernfelt, B ;
Landahl, S ;
Palmertz, B ;
Andreasson, LA ;
Nilsson, L ;
Persson, G ;
Oden, A ;
Svanborg, A .
LANCET, 1996, 347 (9009) :1141-1145
[10]   THE EFFECT OF WHITE-MATTER HYPERINTENSITY VOLUME ON BRAIN STRUCTURE, COGNITIVE PERFORMANCE, AND CEREBRAL METABOLISM OF GLUCOSE IN 51 HEALTHY-ADULTS [J].
DECARLI, C ;
MURPHY, DGM ;
TRANH, M ;
GRADY, CL ;
HAXBY, JV ;
GILLETTE, JA ;
SALERNO, JA ;
GONZALESAVILES, A ;
HORWITZ, B ;
RAPOPORT, SI ;
SCHAPIRO, MB .
NEUROLOGY, 1995, 45 (11) :2077-2084