细胞膜超极化与脑血管调节

被引：4

作者：

张孝清

机构：

[1] 南京医科大学药理学教研室

来源：

国外医学(脑血管疾病分册) | 1997年 / 01期

关键词：

内皮细胞超极化因子; 钾通道; 脑血管调节;

D O I：

暂无

中图分类号：

R33 [人体生理学];

学科分类号：

100123 [人体微生态学];

摘要：

细胞膜超极化是血管,尤其是脑血管舒张调节的重要机制。文章就内皮细胞超极化因子及其作用机制作了介绍。在脑血管,ATP敏感钾通道(KATP)和钙激活钾通道(KCa)在脑血管调节方面起着重要作用。内源性诱导KATP和KCa激活超极化机制与内皮源性因子的作用是相互联系的。在脑缺氧、低血压等病理状态时,其血管舒张机制与钾通道的激活所引起的超极化有关。

引用

页码：3 / 7

页数：5

共 7 条

[1]

ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION - A ROLE IN THE CONTROL OF VASCULAR TONE [J].

GARLAND, CJ ;

PLANE, F ;

KEMP, BK ;

COCKS, TM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1995, 16 (01) :23-30

[2]

Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2 plus-Dependent Kplus Channels.[J].Hisao Taguchi;Donald D. Heistad;Takanari Kitazono;Frank M. Faraci.Circulation Research.1995, 6

[3]

CEREBRAL VASODILATION DURING HYPERCAPNIA - ROLE OF GLIBENCLAMIDE-SENSITIVE POTASSIUM CHANNELS AND NITRIC-OXIDE [J].

FARACI, FM ;

BREESE, KR ;

HEISTAD, DD .

STROKE, 1994, 25 (08) :1679-1683

[4]

EFFECT OF DIABETES-MELLITUS ON FLOW-MEDIATED AND ENDOTHELIUM-DEPENDENT DILATATION OF THE RAT BASILAR ARTERY [J].

FUJII, K ;

HEISTAD, DD ;

FARACI, FM .

STROKE, 1992, 23 (10) :1494-1498

[5]

ENDOTHELINS AND THE NERVOUS-SYSTEM [J].

GREENBERG, DA ;

CHAN, J ;

SAMPSON, HA .

NEUROLOGY, 1992, 42 (01) :25-31

[6]

MECHANISMS OF IMPAIRED ENDOTHELIUM-DEPENDENT CEREBRAL VASODILATATION IN RESPONSE TO BRADYKININ IN HYPERTENSIVE RATS [J].

YANG, ST ;

MAYHAN, WG ;

FARACI, FM ;

HEISTAD, DD .

STROKE, 1991, 22 (09) :1177-1182

[7]

Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation..Lincoln TM; Cornwell TL;.Blood Vessels.1991,

← 1 →