骨骼肌缺血再灌注损伤的机制

被引：25

作者：

刘洋 ^{[1
]}

张宏伟 ^{[1
]}

牟艳 ^{[1
]}

何春水 ^{[2
]}

机构：

[1] 泸州医学院附属医院血管外科

[2] 成都中医药大学附属医院血管外科介入治疗中心

来源：

中国组织工程研究与临床康复 | 2007年 / 45期

关键词：

骨骼肌; 缺血; 再灌注损伤; 氧自由基; 钙超载; 中性粒细胞; 一氧化氮; 无复流; 细胞调亡;

D O I：

暂无

中图分类号：

R685 [肌肉疾病及损伤];

学科分类号：

100220 [骨科学];

摘要：

目的:对近年来骨骼肌缺血再灌注损伤的发病机制进行综述。资料来源:应用计算机检索MEDLINE、CBM、CNKI数据库及手工检索1998-01/2006-11期间的相关文献。中文检索词包括"骨骼肌,缺血再灌注损伤,发病机制";英文检索词有"Skeletal muscle","ischemia and reperfusion injury","oxygen freeradical","calcium overload"和"neutrophil"。资料选择:共收集到相关文献300篇,阅读全部文章的文题和大部分文章的摘要。选择文献所述内容与骨骼肌缺血再灌注损伤机制相关的文献。排除重复性研究。资料提炼:共得到符合纳入条件的文献55篇,排除145篇。选择其中30篇进行分析,英文24篇,中文6篇。资料综合:骨骼肌缺血再灌注损伤的机制由于有许多因素的介入而变的十分复杂,目前主要以氧自由基学说,钙超载学说和中性粒细胞学说为主,同时也注意到了一氧化氮和细胞凋亡以及微循环的无复流现象在其中的作用。结论:氧自由基学说,钙超载学说,中性粒细胞学说,一氧化氮,细胞凋亡以及微循环的无复流现象在骨骼肌缺血再灌注损伤中起着重要作用。

引用

页码：9186 / 9189

页数：4

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