中药逆转P-糖蛋白介导的肿瘤多药耐药的研究进展

被引：21

作者：

沈小玲 ^{[1
]}

胡英杰 ^{[1
]}

禹志领 ^{[2
]}

方宏勋 ^{[2
]}

机构：

[1] 广州中医药大学热带医学研究所

[2] 香港浸会大学中医药学院研发部

来源：

中国天然药物 | 2009年 / 7卷 / 06期

关键词：

多药耐药; P-糖蛋白; P-糖蛋白调节剂;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

多药耐药(MDR)是导致癌症化疗失败的主要因素。肿瘤产生MDR的机制很多,其中最为常见也研究得较为深入的一种机制是一种ATP依赖跨膜转运蛋白P-糖蛋白(P-gp)在肿瘤细胞中的过度表达。由于相当一部分化疗药物属于P-gp的转运底物,过度表达的P-gp使细胞内药物浓度显著低于有效毒性浓度,从而产生耐药性。P-gp调节剂可通过抑制P-gp的转运功能或者抑制蛋白的表达修复肿瘤细胞对药物的敏感性。本文就近年来在部分中药及中药单体成分逆转肿瘤P-gp-MDR作用方面的研究做一些总结。

引用

收藏

页码：465 / 475

页数：11

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