卡配因与缺血性脑损伤

被引：5

作者：

邓志宽

董为伟

机构：

[1] 第三军医大学新桥医院神经内科

[2] 重庆医科大学第一附属医院神经病学研究所重庆

来源：

国外医学脑血管疾病分册 | 2002年 / 03期

关键词：

卡配因; 缺血性脑损伤;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

研究表明,卡配因过度激活参与了缺血性脑损伤的病理过程。卡配因可能通过降解细胞骨架和结构蛋白、eIF-4和细胞内重要调节蛋白,破坏线粒体膜引起ATP生成障碍和MTP开放,并使溶酶体膜破裂,从而导致脑损伤。卡配因过度激活还可引起神经元发生坏死和凋亡,并与白质缺血性损伤也有重要关系。

引用

页码：223 / 225

页数：3

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