Caspase-3参与缺血性神经元凋亡通路的研究

被引：7

作者：

赵炜疆

徐超

机构：

[1] 北京市神经外科研究所

来源：

国外医学脑血管疾病分册 | 2002年 / 05期

关键词：

caspase-3; 卡配因; 脑缺血; 神经元保护;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

Caspase-3是胱冬肽酶家族中的重要成员,它通过介导和执行死亡指令在缺血性的神经元凋亡过程中发挥重要作用。Caspase-3参与脑缺血神经元凋亡通路,包括caspase-3的激活途径、主要的调控机制以及它和另一个与细胞死亡密切相关的蛋白酶卡配因的关系。明确caspase-3在缺血性神经元凋亡通路中的作用,深入探讨其激活和调控机制,对脑缺血神经元的保护具有重要意义。

引用

页码：391 / 394

页数：4

共 7 条

[1]

Calpastatin is upregulated in response to hypoxia and is a suicide substrate to Calpain after neonatal cerebral hypoxia-ischemia..Blomgren K; Hallin U; Andersson AL; et al;.Journal of Biological Chemistry.1999,

[2]

Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage..Hara H; Friedlander R M; Gagliardini V; et al;.Proc Natl Acad Sci U S A.1997,

[3]

Cloning and characterization of rat caspase-9: Implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia [J].

Cao, GD ;

Luo, YM ;

Nagayama, T ;

Pei, W ;

Stetler, RA ;

Graham, SH ;

Chen, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2002, 22 (05) :534-546

[4]

Regulation of caspases and XIAP in the brain after asphyxial cardiac arrest in rats.[J].Laurence M. Katz;George Lotocki;Yuanfan Wang;Susan Kraydieh;W. Dalton Dietrich;Robert W. Keane.Neuroreport.2001, 17

[5]

Caspase mRNA expression in a rat model of focal cerebral ischemia.[J].David C Harrison;Robert P Davis;Brian C Bond;Colin A Campbell;Michael F James;Andrew A Parsons;Karen L Philpott.Molecular Brain Research.2001, 1

[6]

Intracellular Bax translocation after transient cerebral ischemia: Implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death [J].

Cao, GD ;

Minami, M ;

Pei, W ;

Yan, CH ;

Chen, DX ;

O'Horo, C ;

Graham, SH ;

Chen, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (04) :321-333

[7]

Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’.[J]..European Journal of Neuroscience.1998, 9

← 1 →