电针抑制骨性关节炎的炎症反应及延缓关节软骨退变

被引：19

作者：

吴明霞 ^{[1
]}

李西海 ^{[2
]}

吴广文 ^{[2
]}

李俐 ^{[1
]}

陈文列 ^{[3
]}

刘献祥 ^{[3
]}

机构：

[1] 福建中医药大学附属第二人民医院针灸科

[2] 福建中医药大学中西医结合研究院

[3] 福建省中西医结合老年性疾病重点实验室

来源：

中国组织工程研究与临床康复 | 2011年 / 15卷 / 50期

关键词：

骨性关节炎; 电针; 细胞因子; 关节软骨; 退变; 骨组织构建;

D O I：

暂无

中图分类号：

R245 [针灸学、针灸疗法];

学科分类号：

100517 [针灸学];

摘要：

背景:研究表明电针能有效缓解骨性关节炎的临床症状。目的:观察电针抑制骨性关节炎的炎症反应及保护关节软骨的作用机制。方法:采用木瓜蛋白酶双膝关节腔注射复制SD大鼠骨性关节炎模型,建模成功后分别电针内、外膝眼(EX-LE4,EX-LE5)治疗5,15,30min/d。结果与结论:与模型组比较,经电针15,30min/d治疗的骨性关节炎模型大鼠血液中P物质及关节液中白细胞介素1、白细胞介素6、肿瘤坏死因子α和基质金属蛋白酶3的质量浓度明显减少(P<0.05),血液中瘦素及关节液中基质金属蛋白酶抑制因子1的水平明显增加(P<0.05),同时软骨退变的程度明显减轻(P<0.05,P<0.01)。证实电针能有效减轻大鼠膝骨性关节炎的炎症反应,延缓关节软骨的退变。

引用

页码：9410 / 9414

页数：5

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