氧化应激与脑缺血-再灌注损伤

被引：58

作者：

王钊 ^{[1
]}

黄雨蒙 ^{[1
]}

彭军 ^{[2
]}

机构：

[1] 中南大学湘雅医学院

[2] 中南大学药学院药理学系

来源：

国际病理科学与临床杂志 | 2012年 / 32卷 / 04期

关键词：

脑缺血-再灌注损伤; 氧化应激; 抗氧化治疗;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

100204 [神经病学];

摘要：

脑缺血-再灌注损伤是一个复杂的级联反应过程,涉及多种机制,其中氧化应激起到关键作用。目前的研究表明,氧化应激可以通过脂质过氧化、蛋白质变性和/或DNA修饰等途径促使神经细胞坏死,也可以通过线粒体、内质网或死亡受体等途径启动神经细胞凋亡。本文就氧化应激在脑缺血-再灌注损伤中的作用机制及抗氧化治疗的新进展作一综述。

引用

页码：343 / 346

页数：4

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