骨关节炎发生发展的分子机制

被引：44

作者：

尹若峰

邱贵兴

机构：

[1] 中国医学科学院北京协和医学院北京协和医院骨科

来源：

中国骨与关节外科 | 2009年 / 2卷 / 01期

关键词：

骨关节炎; 分子作用机制;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎(osteoarthritis,OA)是一种退行性疾病,其发生发展主要是由于机械应力和关节退变所引起的膝关节软骨组织损伤和软骨下骨硬化。近年来的基础研究发现,除了机械应力作用之外,软骨组织本身也发生一系列改变,造成了软骨损伤的加重或干扰其修复功能。本文从分子作用角度对OA的发生发展做一综述,帮助骨科医师了解该疾病在基础研究方面的最新进展,为临床研究提供一些参考。

引用

页码：71 / 73

页数：3

共 8 条

[1]

Cellular events leading to chondrocyte death after cartilage impact injury [J].

Green, D. M. ;

Noble, P. C. ;

Ahuero, J. S. ;

Birdsall, H. H. .

ARTHRITIS AND RHEUMATISM, 2006, 54 (05) :1509-1517

[2]

Polymorphism in signal transduction is a major route through which osteoarthritis susceptibility is acting [J].

Loughlin, J .

CURRENT OPINION IN RHEUMATOLOGY, 2005, 17 (05) :629-633

[3]

Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis – results of a 1 year longitudinal arthroscopic study in 422 patients.[J].X. Ayral;E.H. Pickering;T.G. Woodworth;N. Mackillop;M. Dougados.Osteoarthritis and Cartilage.2005, 5

[4]

Osteoarthritis: Is it a disease of cartilage or of bone? [J].

Felson, DT ;

Neogi, T .

ARTHRITIS AND RHEUMATISM, 2004, 50 (02) :341-344

[5]

Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression [J].

Kurz, B ;

Lemke, A ;

Kehn, M ;

Domm, C ;

Patwari, P ;

Frank, EH ;

Grodzins, AJ ;

Schünke, M .

ARTHRITIS AND RHEUMATISM, 2004, 50 (01) :123-130

[6]

Inflammation and angiogenesis in osteoarthritis [J].

Haywood, L ;

McWilliams, DF ;

Pearson, CI ;

Gill, SE ;

Ganesan, A ;

Wilson, D ;

Walsh, DA .

ARTHRITIS AND RHEUMATISM, 2003, 48 (08) :2173-2177

[7]

The role of reactive oxygen species in homeostasis and degradation of cartilage [J].

Henrotin, YE ;

Bruckner, P ;

Pujol, JPL .

OSTEOARTHRITIS AND CARTILAGE, 2003, 11 (10) :747-755

[8]

Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage - A possible mechanism through which age is a risk factor for osteoarthritis [J].

Verzijl, N ;

DeGroot, J ;

Ben Zaken, C ;

Braun-Benjamin, O ;

Maroudas, A ;

Bank, RA ;

Mizrahi, J ;

Schalkwijk, CG ;

Thorpe, SR ;

Baynes, JW ;

Bijlsma, JWJ ;

Lafeber, FPJG ;

TeKoppele, JM .

ARTHRITIS AND RHEUMATISM, 2002, 46 (01) :114-123

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