脑积水所致病理生理变化的研究现状

被引：16

作者：

唐健

邓锐

机构：

[1] 四川省人民医院神经外科

[2] 四川省第五人民医院内科

来源：

国外医学(神经病学神经外科学分册) | 2003年 / 04期

关键词：

脑积水; 病理生理; 分流术;

D O I：

暂无

中图分类号：

R651.1 [颅脑];

学科分类号：

摘要：

脑积水发展过程中伴随着脑室周围结构乃至全脑的一系列病理生理变化,若无及时有效的干预措施,这些改变会导致严重的神经功能废损。这一病变过程包括机械性压迫和牵拉作用力、缺血缺氧、脑水肿、血脑屏障功能障碍等原发机制以及细胞死亡、脑血管数量和管径的减少、轴索和传导通路的损害、胶质增生、代谢改变等继发损伤,而皮层神经元的凋亡和白质广泛的胶质增生是造成脑积水不可逆损害的主要原因。早期干预能使脑积水所致的病变有相当程度的恢复。

引用

页码：378 / 383

页数：6

共 11 条

[1] Sodium channel-blocking agents are not of benefit to rats with kaolin-induced hydrocephalus [J].

Del Bigio, MR ;

Wang, X ;

Wilson, MJ .

NEUROSURGERY, 2002, 51 (02) :460-466

[2] Changes in cortical and cerebellar bcl-2 mRNA levels in the developing hydrocephalic rat (LEW-HYR) as measured by a real time quantified RT-PCR [J].

Yamada, Y ;

Watanabe, Y ;

Zhang, J ;

Haraoka, J ;

Ito, H .

NEUROSCIENCE, 2002, 114 (01) :165-171

[3]

Axonal damage associated with enlargement of ventricles during hydrocephalus: A silver impregnation study[J] . Ding,McAllister,Yao,Yan,Canady.Neurological Research . 2001 (6)

[4] Neuron tolerance during hydrocephalus [J].

Ding, Y ;

McAllister, JP ;

Yao, B ;

Yan, N ;

Canady, AI .

NEUROSCIENCE, 2001, 106 (04) :659-667

[5] Magnetic resonance imaging study of extracellular fluid tracer movement in brains of immature rats with hydrocephalus [J].

Shoesmith, CL ;

Buist, R ;

Del Bigio, MR .

NEUROLOGICAL RESEARCH, 2000, 22 (01) :111-116

[6] The microglial response to progressive hydrocephalus in a model of inherited aqueductal stenosis [J].

Mangano, FT ;

McAllister, JP ;

Jones, HC ;

Johnson, MJ ;

Kriebel, RM .

NEUROLOGICAL RESEARCH, 1998, 20 (08) :697-704

[7]

Cell Death, Axonal Damage, and Cell Birth in the Immature Rat Brain Following Induction of Hydrocephalus[J] . Marc R. Del Bigio,Yi Wei Zhang.Experimental Neurology . 1998 (1)

[8] GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination [J].