骨关节炎和骨质疏松:骨髓间充质干细胞与成骨细胞

被引:2
作者
金文杰
戴力扬
机构
[1] 上海交通大学医学院附属新华医院骨科
关键词
骨关节炎; 骨质疏松; 骨髓基质干细胞; 骨细胞; 骨代谢;
D O I
暂无
中图分类号
R684.3 [关节炎]; R580 [];
学科分类号
摘要
骨关节炎和骨质疏松是最常见的两种骨代谢异常疾病。骨髓间充质干细胞和成骨细胞广泛存在于骨髓及松质骨中,对骨代谢有重要作用。本文对近年关于骨髓间充质干细胞和成骨细胞与这两种疾病关系的研究结果进行一综述,分析这两类细胞在不同骨代谢异常中的特点,以此增加对骨关节炎和骨质疏松发病机制的认识,希望能为临床更有针对性诊疗和预防骨代谢异常疾病提供一定帮助。
引用
收藏
页码:499 / 504
页数:6
相关论文
共 17 条
  • [1] Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study[J] . J. Velasco,M. T. Zarrabeitia,J. R. Prieto,J. L. Perez-Castrillon,M. D. Perez-Aguilar,M. I. Perez-Nu?ez,C. Sa?udo,J. Hernandez-Elena,I. Calvo,F. Ortiz,J. Gonzalez-Macias,J. A. Riancho.Osteoporosis International . 2009 (1)
  • [2] Aromatase expression in osteoarthritic and osteoporotic bone
    Hernandez, Jose L.
    Garces, Carlos A.
    Sumillera, Manuel
    Fernandez-Aldasoro, Eugenio V.
    Garcia-Ibarbia, Carmen
    Ortiz-Gomez, Jesus A.
    Arozamena, Jana
    Alonso, Maria A.
    Riancho, Jose A.
    [J]. ARTHRITIS AND RHEUMATISM, 2008, 58 (06): : 1696 - 1700
  • [3] Increased adipogenesis of osteoporotic human‐mesenchymal stem cells (MSCs) characterizes by impaired leptin action[J] . PabloAstudillo,SusanaRíos,LuisPastenes,Ana MaríaPino,J. PabloRodríguez.J. Cell. Biochem. . 2008 (4)
  • [4] Wnt signaling and the regulation of bone mass
    Baron R.
    Rawadi G.
    [J]. Current Osteoporosis Reports, 2007, 5 (2) : 73 - 80
  • [5] Expression of bone resorption genes in osteoarthritis and in osteoporosis
    Logar, Darja Bitenc
    Komadina, Radko
    Prezelj, Janez
    Ostanek, Barbara
    Trost, Zoran
    Marc, Janja
    [J]. JOURNAL OF BONE AND MINERAL METABOLISM, 2007, 25 (04) : 219 - 225
  • [6] Different responsiveness to mechanical stress of bone cells from osteoporotic versus osteoarthritic donors
    Bakker, A. D.
    Klein-Nulend, J.
    Tanck, E.
    Heyligers, I. C.
    Albers, G. H.
    Lips, P.
    Burger, E. H.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2006, 17 (06) : 827 - 833
  • [7] Expression profiles and functional analyses of Wnt-related genes in human joint disorders
    Nakamura, Y
    Nawata, M
    Wakitani, S
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (01) : 97 - 105
  • [8] Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects[J] . Addolorata Corrado,Francesco Paolo Cantatore,Maria Grano,Silvia Colucci.Clinical Rheumatology . 2005 (5)
  • [9] Expression of ICAM-1 by osteoblasts in healthy individuals and in patients suffering from osteoarthritis and osteoporosis
    Lavigne, P
    Benderdour, M
    Lajeunesse, D
    Shi, Q
    Fernandes, JC
    [J]. BONE, 2004, 35 (02) : 463 - 470
  • [10] Osteoarthritis and osteoporosis: Clinical and research evidence of inverse relationship[J] . Jan Dequeker,Jeroen Aerssens,Frank P. Luyten.Aging Clinical and Experimental Research . 2003 (5)