糖尿病性冠状动脉粥样硬化机制的研究进展

被引：9

作者：

胡龙江

吕湛

机构：

[1] 川北医学院附属医院心血管内科

来源：

国际病理科学与临床杂志 | 2009年 / 29卷 / 05期

关键词：

糖尿病; 动脉粥样硬化; 清道夫受体; 内质网应激; L-精氨酸;

D O I：

暂无

中图分类号：

R587.1 [糖尿病]; R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

糖尿病患者患冠状动脉粥样硬化性心脏病的发病率是非糖尿病的4倍,近几年来提出的相关发病机制包括Am adori型糖基化合物作用、羧甲基赖氨酸形成、清道夫受体上调、泛素-蛋白酶体系统激活、内质网应激、精氨酸代谢异常、激活血小板源性生长因子途径、透明质烷代谢紊乱和瘦素水平改变等。这些机制的阐述,有利于指导临床对糖尿病性冠状动脉粥样硬化性心脏病及其并发症的预防和治疗。

引用

页码：445 / 450

页数：6

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