ERK信号通路的信号转导调控机制

被引：48

作者：

赵明哲 ^{[1
,2
]}

刘靖华 ^{[2
]}

李玉花 ^{[1
]}

姜勇 ^{[2
]}

机构：

[1] 东北林业大学生命科学学院发育生物学实验室

[2] 南方医科大学广东省蛋白质组学重点实验室

来源：

国际病理科学与临床杂志 | 2009年 / 29卷 / 01期

关键词：

激酶; 亚细胞定位; 支架蛋白; 信号调控;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

胞外信号调控激酶(ERK)是发现的第1个丝裂原活化蛋白激酶(MAPK),它调控多种重要的细胞生物学过程,包括细胞增殖、分化和凋亡等。ERK信号级联反应能够特异地介导广泛的生物学过程,其机制主要是通过信号的反馈调控,与支架蛋白的相互作用,亚细胞定位的改变,在级联反应的每一个环节存在不同功能的多种组分,细胞内非磷酸酶抑制物和G蛋白等的调控实现的。

引用

收藏

页码：15 / 19

页数：5

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