骨关节炎分子机制及作用靶点研究进展

被引：11

作者：

张志奇

廖威明

傅明

机构：

[1] 中山大学附属第一医院关节外科

来源：

中国骨与关节外科 | 2008年 / 1卷 / 01期

关键词：

骨关节炎; 生理; 病理;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

本文回顾了骨关节炎主要细胞通路的国内外最新研究进展,特别是较详细地介绍了有研究前景的治疗靶点,如滑膜炎白介素一1信号通路的靶点、软骨破坏Wnt信号通路的靶点,旨在为未来针对这些靶点的干预与调节提供新的思路与依据。调节这些靶点将有利于改善骨关节炎组织成分中合成与分解代谢失衡的问题,从而达到治疗骨关节炎的目的。

引用

收藏

页码：61 / 66

页数：6

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