JNK介导的细胞凋亡在发育与疾病中的作用

被引：6

作者：

项文娟

张英杰

朱明伟

李明发

机构：

[1] 上海交通大学生命科学技术学院

来源：

细胞生物学杂志 | 2009年 / 31卷 / 01期

基金：

教育部留学回国人员科研启动基金;

关键词：

JNK; 细胞凋亡; 死亡受体途径; 线粒体途径; 发育与疾病;

D O I：

暂无

中图分类号：

R33 [人体生理学]; R363 [病理生理学];

学科分类号：

1001 ; 100104 ;

摘要：

JNK作为进化保守的MAPKs成员之一在生物体内发挥重要的生理功能。大量实验证据表明,JNK介导的信号通路广泛参与调节增殖、凋亡、运动、代谢及DNA损伤修复等细胞生命过程,而JNK信号功能的失调则与多种疾病如缺血/再灌注损伤、神经退行性疾病、糖尿病及癌症等的发生直接相关。近年来,有关该领域的研究已获得了重要突破与进展。现主要介绍JNK信号通路作用于细胞凋亡的分子机制,同时,重点论述JNK介导的细胞凋亡在机体发育中的意义及其失调后所导致的病理变化。

引用

页码：21 / 27

页数：7

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