泛素羧基末端水解酶-1的研究进展

被引：16

作者：

刘媛

张志刚

机构：

[1] 复旦大学上海医学院病理学系

来源：

国际病理科学与临床杂志 | 2008年 / 28卷 / 06期

关键词：

泛素羧基末端水解酶-1; 蛋白基因产物9.5; 去泛素化酶; 泛素-蛋白酶体通路;

D O I：

暂无

中图分类号：

Q55 [酶];

学科分类号：

070307 [化学生物学];

摘要：

泛素羧基末端水解酶-1(UCH-L1),又名蛋白基因产物9.5,是泛素-蛋白酶体系统中的重要成员,它除了去泛素化作用外,还具有泛素连接酶和稳定细胞内泛素单体的功能。UCH-L1通过泛素相关途径调节细胞的增生、分化和凋亡,并可能参与与之相关的神经退行性疾病、肿瘤等的发生发展过程。最近UCH-L1的特异性底物的发现为探讨其作用的具体机制开辟了新的途径。

引用

页码：544 / 549

页数：6

共 22 条

[1]

Anaplastic Sarcoma of the Kidney: A Clinicopathologic Study of 20 Cases of a New Entity With Polyphenotypic Features.[J]..The American Journal of Surgical Pathology.2007, 10

[2]

S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden [J].

Belin, Andrea Carmine ;

Westerlund, Marie ;

Bergman, Olle ;

Nissbrandt, Hans ;

Lind, Charlotta ;

Sydow, Olof ;

Galter, Dagmar .

PARKINSONISM & RELATED DISORDERS, 2007, 13 (05) :295-298

[3]

Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease: An initial assessment [J].

Butterfield, D. Allan ;

Gnjec, Anastazija ;

Poon, H. Fai ;

Castegna, Alessandra ;

Pierce, William M. ;

Klein, Jon B. ;

Martins, Ralph N. .

JOURNAL OF ALZHEIMERS DISEASE, 2006, 10 (04) :391-397

[4]

Ubiquitin hydrolase Uch-L1 rescues β-amyloid-induced decreases in synaptic function and contextual memory [J].

Gong, Bing ;

Cao, Zixuan ;

Zheng, Ping ;

Vitolo, Ottavio V. ;

Liu, Shumin ;

Staniszewski, Agnieszka ;

Moolman, Donna ;

Zhang, Hong ;

Shelanski, Michael ;

Arancio, Ottavio .

CELL, 2006, 126 (04) :775-788

[5]

Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.[J].Bharat B. Aggarwal;Sanjeev Banerjee;Uddalak Bharadwaj;Bokyung Sung;Shishir Shishodia;Gautam Sethi.Biochemical Pharmacology.2006, 7

[6]

Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy [J].

Sekiguchi, Satoshi ;

Kwon, Jungkee ;

Yoshida, Etsuko ;

Hamasaki, Hiroko ;

Ichinose, Shizuko ;

Hideshima, Makoto ;

Kuraoka, Mutsuki ;

Takahashi, Akio ;

Ishii, Yoshiyuki ;

Kyuwa, Shigeru ;

Wada, Keiji ;

Yoshikawa, Yasuhiro .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (05) :1722-1729

[7]

Gene expression in the LNCaP human prostate cancer progression model: Progression associated expression in vitro corresponds to expression changes associated with prostate cancer progression in vivo [J].

Chen, Qian ;

Watson, Jeffery T. ;

Marengo, Susan Ruth ;

Decker, Keith S. ;

Coleman, Ilsa ;

Nelson, Peter S. ;

Sikes, Robert A. .

CANCER LETTERS, 2006, 244 (02) :274-288

[8]

UCHL-1 is not a Parkinson's disease susceptibility gene [J].

Healy, DG ;

Abou-Sleiman, PM ;

Casas, JP ;

Ahmadi, KR ;

Lynch, T ;

Gandhi, S ;

Muqit, MMK ;

Foltynie, T ;

Barker, R ;

Bhatia, KP ;

Quinn, NP ;

Lees, AJ ;

Gibson, JM ;

Holton, JL ;

Revesz, T ;

Goldstein, DB ;

Wood, NW .

ANNALS OF NEUROLOGY, 2006, 59 (04) :627-633

[9]

Ubiquitin C-Terminal Hydrolase L-1 Is Essential for the Early Apoptotic Wave of Germinal Cells and for Sperm Quality Control During Spermatogenesis<sup>1</sup>.[J].Jungkee Kwon;Keiji Mochida;Yu-Lai Wang;Satoshi Sekiguchi;Tadashi Sankai;Shunsuke Aoki;Atsuo Ogura;Yasuhiro Yoshikawa;Keiji Wada.Biology of Reproduction.2005, 1

[10]

Gefitinib-responsive EGFR-positive colorectal cancers have different proteome profiles from non-responsive cell lines [J].

Loeffler-Ragg, J ;

Skvortsov, S ;

Sarg, B ;

Skvortsova, I ;

Witsch-Baumgartner, M ;

Mueller, D ;

Lindner, H ;

Zwierzina, H .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (15) :2338-2346

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