胰岛素抵抗与脂肪肝

被引:27
作者
顾鸣宇
机构
[1] 上海市第一人民医院内分泌科上海
关键词
胰岛素抵抗; 脂肪肝; 非酒精性脂肪性肝炎;
D O I
暂无
中图分类号
R575.5 [肝代谢障碍];
学科分类号
摘要
目前越来越多的研究提示胰岛素抵抗是代谢综合征的病理生理基础,而胰岛素抵抗又与血循环、肝细胞内的游离脂肪酸的蓄积、脂肪细胞中肿瘤坏死因子-α超表达以及铁的蓄积、瘦素等因素息息相关,从而影响脂肪肝和非酒精性脂肪性肝炎的发病,因此胰岛素抵抗可能并不是脂肪肝的继发改变,而可能是其原发始动因素。
引用
收藏
页码:32 / 33
页数:2
相关论文
共 6 条
[1]  
Tumor necrosis factor a promoter polymorphisms and insulinp resistance in nonalcoholic fatty liver disease.[J].Luca Valenti;Anna Ludovica Fracanzani;Paola Dongiovanni;Gennaro Santorelli;Adriana Branchi;Emanuela Taioli;Gemino Fiorelli;Silvia Fargion.Gastroenterology.2002, 2
[2]   Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities [J].
Sanyal, AJ ;
Campbell-Sargent, C ;
Mirshahi, F ;
Rizzo, WB ;
Contos, MJ ;
Sterling, RK ;
Luketic, VA ;
Shiffman, ML ;
Clore, JN .
GASTROENTEROLOGY, 2001, 120 (05) :1183-1192
[3]   Cytokines in alcoholic liver disease [J].
McClain, CJ ;
Barve, S ;
Deaciuc, I ;
Kugelmas, M ;
Hill, D .
SEMINARS IN LIVER DISEASE, 1999, 19 (02) :205-219
[4]   Leptin, obesity, and liver disease [J].
Kaplan, LM .
GASTROENTEROLOGY, 1998, 115 (04) :997-1001
[5]   Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis [J].
George, DK ;
Goldwurm, S ;
MacDonald, GA ;
Cowley, LL ;
Walker, NI ;
Ward, PJ ;
Jazwinska, EC ;
Powell, LW .
GASTROENTEROLOGY, 1998, 114 (02) :311-318
[6]   Steatohepatitis: A tale of two "hits"? [J].
Day, CP ;
James, OFW .
GASTROENTEROLOGY, 1998, 114 (04) :842-845