骨髓间充质干细胞的免疫学特性及其同种异体的应用研究进展

被引：1

作者：

武京国

曹谊林

肖苒

机构：

[1] 中国医学科学院整形外科医院研究中心

来源：

组织工程与重建外科杂志 | 2012年 / 8卷 / 01期

关键词：

骨髓间充质干细胞; 同种异体; 再生医学; 组织工程; 免疫调节;

D O I：

暂无

中图分类号：

R329 [人体组织学];

学科分类号：

100101 ;

摘要：

骨髓间充质干细胞(Bone mesenchymal stem cells,BMSCs)具有多向分化潜能,低免疫原性,同种异体移植后能够调节机体免疫,因此逐渐成为再生医学和免疫学研究的热点。同种异体BMSCs(Allogeneic,allo-BMSCs)在再生医学、组织工程和免疫调节等方面的应用研究显示出了广阔的发展前景,但在进入临床应用前还有很多问题需要解决。本文就骨髓间充质干细胞的免疫学特性及其同种异体的应用研究进展进行综述。

引用

页码：49 / 52

页数：4

共 12 条

[1] 骨髓移植诱导临床心脏移植后供者特异性免疫耐受方案的探讨 [J].

郭可泉 ;

孟旭 ;

余元龙 ;

韩杰 ;

姜海明 ;

许晓军 ;

陆小军 ;

贾一新 ;

郑俊猛 ;

张海波 ;

李岩 ;

郑铁 ;

许春雷 ;

曾文 ;

王坚刚 ;

崔永强 ;

罗天戈 ;

王珺 ;

IKeharaSusumu .

中华器官移植杂志, 2011, (01)

[2] Cell-dose-dependent increases in circulating levels of immune effector cells in rhesus macaques following intracranial injection of allogeneic MSCs [J].

Isakova, Iryna A. ;

Dufour, Jason ;

Lanclos, Calvin ;

Bruhn, Julie ;

Phinney, Donald G. .

EXPERIMENTAL HEMATOLOGY, 2010, 38 (10) :957-967

[3] Immunological Study of Allogeneic Mesenchymal Stem Cells during Bone Formation [J].

Guo, S. Q. ;

Xu, J. Z. ;

Zou, Q. M. ;

Jiang, D. M. .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2009, 37 (06) :1750-1759

[4] Allogenic mesenchymal stem cell transplantation has a therapeutic effect in acute myocardial infarction in rats [J].

Imanishi, Yukiko ;

Salto, Atsuhiro ;

Komoda, Hiroshi ;

Kitagawa-Sakakida, Satoru ;

Miyagawa, Shigeru ;

Kondoh, Haruhiko ;

Ichikawa, Hajime ;

Sawa, Yoshiki .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 44 (04) :662-671

[5] Mesenchymal stem cells stimulate antibody secretion in human B cells [J].

Rasmusson, I. ;

Le Blanc, K. ;

Sundberg, B. ;

Ringden, O. .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2007, 65 (04) :336-343

[6] Benefit and risk in tissue engineering [J].

Williams, David .

MATERIALS TODAY, 2004, 7 (05) :24-29

[7] HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells [J].

Le Blanc, K ;

Tammik, C ;

Rosendahl, K ;

Zetterberg, E ;

Ringdén, O .

EXPERIMENTAL HEMATOLOGY, 2003, 31 (10) :890-896

[8]

Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation[J] . William T. Tse,John D. Pendleton,Wendy M. Beyer,Matthew C. Egalka,Eva C. Guinan. Transplantation . 2003 (3)

[9] Inducing tolerance to MHC-matched allogeneic islet grafts in diabetic NOD mice by simultaneous islet and bone marrow transplantation under nonirradiative and nonmyeloablative conditioning therapy [J].

Wu, T ;

Levay-Young, B ;

Heuss, N ;

Sozen, H ;

Kirchhof, N ;

Sutherland, DER ;

Hering, B ;

Guo, ZG .

TRANSPLANTATION, 2002, 74 (01) :22-27

[10]

Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial[J] . Eriko Tateishi-Yuyama,Hiroaki Matsubara,Toyoaki Murohara,Uichi Ikeda,Satoshi Shintani,Hiroya Masaki,Katsuya Amano,Yuji Kishimoto,Kohji Yoshimoto,Hidetoshi Akashi,Kazuyuki Shimada,Toshiji Iwasaka,Tsutomu Imaizumi. The Lancet . 2002 (9331)

← 1 2 →