金属与淀粉样β肽的相互作用:阿尔茨海默症的分子机制初探

被引：3

作者：

焦勇

杨频

机构：

[1] 山西大学分子科学研究所,化学生物学与分子工程教育部重点实验室

来源：

中国科学(B辑:化学) | 2007年 / 03期

关键词：

阿尔茨海默症; Aβ肽; 铜离子; 锌离子; 分子机理; 聚集; 活性氧物种; 离子通道;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100205 ;

摘要：

从金属-淀粉样β肽(Amyloid-β peptide,Aβ)相互作用的角度评述了锌、铜等金属离子诱导Aβ聚集、催化产生活性氧物种,以及与Aβ的类离子通道结构相互作用等的分子机理,并简要介绍了基于这一机理的治疗药物研究.阿尔茨海默症(AD)分子机理研究的迅猛进展,使人们看到了最终制服AD的一线曙光.

引用

页码：235 / 247

页数：13

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