血清胱抑素C与脑白质病变的相关性研究

被引：8

作者：

孙梦姣

张莉莉

黎炳护

龙春燕

皮燕

郭露

李敬诚

机构：

[1] 第三军医大学大坪医院野战外科研究所神经内科

来源：

第三军医大学学报 | 2016年 / 38卷 / 05期

关键词：

胱抑素C; 脑白质病变; 脑小血管病;

D O I：

暂无

中图分类号：

R742 [脑部疾病];

学科分类号：

1002 ;

摘要：

目的探讨血清胱抑素C(Cystatin C,Cys C)水平和脑白质病变(white matter lesions,WMLs)的相关性。方法收集2014年7月至2015年3月本科住院患者资料,胶体金免疫增强法检测血清Cys C水平,颅脑MRI检查评估脑白质病变,采用Fazekas标准分别对患者脑室旁脑白质病变(P-WMLs)和深部脑白质病变(D-WMLs)的严重程度进行评价,危险因素的分析采用有序多分类Logistic回归分析。结果共473例患者纳入研究,男性190例,年龄(65.7±9.1)岁。重度(0.82±0.18)和中度P-WMLs患者(0.78±0.15)血清Cys C水平均高于轻度P-WMLs患者(0.73±0.14),重度(0.82±0.18)和中度D-WMLs患者(0.79±0.16)血清Cys C水平同样高于轻度D-WMLs患者(0.74±0.14),差异均有统计学意义(P<0.05),二者均提示随着WMLs病变程度的增加Cys C水平也越高。多因素有序多分类Logistic回归分析结果显示,高水平的Cys C(P-WMLs:OR=8.21,95%CI=2.18～30.88;D-WMLs:OR=7.01,95%CI=1.69～29.11)、年龄(P-WMLs:OR=5.18,95%CI=2.81～9.55;DWMLs:OR=4.32,95%CI=2.05～9.08)和高血压(P-WMLs:OR=3.46,95%CI=2.30～5.21;D-WMLs:OR=3.52,95%CI=2.21～5.62)均为WMLs严重程度增加的危险因素。结论血清Cys C水平与WMLs病变程度呈正相关;高水平Cys C、高龄及高血压是WMLs病变严重程度增加的危险因素。

引用

页码：511 / 516

页数：6

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