去甲肾上腺素和麻醉镇痛

被引：1

作者：

葛志军

机构：

[1] 徐州医学院江苏省麻醉学重点实验室()

来源：

国外医学麻醉学与复苏分册. | 2003年 / 06期

关键词：

去甲肾上腺素; 镇痛; 麻醉药;

D O I：

暂无

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

在具有完整的中枢去甲肾上腺素(NA)能神经系统的前提下,NA通过作用于中枢α1或(和)α2受体来影响不同麻醉药的镇痛作用,破坏中枢NA能神经系统的完整性亦如此。脊髓NA能神经系统在麻醉药的镇痛机制中发挥着重要作用。在脊髓水平,NA可通过α1受体使脊髓胶质层抑制性神经元去极化而促进γ-氨基丁酸及甘氨酸的释放;经α2受体抑制脊髓初级传入纤维末梢释放谷氨酸和P物质,并使脊髓背根神经节细胞和脊髓胶质层神经元超极化来增强或介导麻醉药的镇痛作用。

引用

页码：375 / 377

页数：3

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