Ⅱ型胶原分解产物与骨关节炎软骨退变的研究现状

被引：4

作者：

项卫卫

魏波

谭宏昌

机构：

[1] 广东医学院附属医院骨科一区

来源：

广东医学院学报 | 2010年 / 28卷 / 05期

关键词：

骨关节炎; 软骨; Ⅱ型胶原; 降解; 综述文献;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎是一种以关节软骨退行性变、继发性骨质增生为主要特征的慢性退变性关节疾病。软骨基质的降解在关节软骨退变过程中起了主要作用。Ⅱ型胶原分解后的片段被实验证明有诱发骨关节炎和促进软骨降解作用,其机制可能与整合素α2β1、α5β1和膜联蛋白V受体、细胞免疫或反馈机制等有关,但具体机制有待进一步研究明确。该文综述了Ⅱ型胶原的分解产物与骨关节炎软骨退变的研究现状。

引用

收藏

页码：575 / 576

页数：2

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