5-氟尿嘧啶诱导细胞凋亡的分子机制

被引：6

作者：

程宏

刘彦信

郑德先

机构：

[1] 中国协和医科大学基础医学院中国医学科学院基础医学研究所医学分子生物学国家重点实验室

来源：

中国医学文摘(肿瘤学) | 2003年 / 17卷 / 01期

关键词：

细胞凋亡; 线粒体膜; 分子机制; 细胞凋亡途径;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

摘要：

<正> 5-氟尿嘧啶(5-FU)是嘧啶类抗代谢药物,临床作为肿瘤的化疗药物已有30多年的历史,目前是大多数肿瘤治疗的常用药物之一,并为乳腺癌、头颈部肿瘤和大肠癌治疗的首选药。研究表明5-FU的抗肿瘤作用与其参与代谢相关。5-FU与内源性核酸前体尿嘧啶结构上差别只在于嘧啶环上第5位的碳被氟原子置换,生物学特性与天然嘧啶相似,决定5-FU能以多种形式参与细胞的生命活动,如取代天然的

引用

页码：75 / 76

页数：2

共 8 条

[1] Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma [J].

Kim, R ;

Tanabe, K ;

Inoue, H ;

Toge, T .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2002, 20 (03) :549-555

[2] Treatment of human colon carcinoma cell lines with anti-neoplastic agents enhances their lytic sensitivity to antigen-specific CD8+ cytotoxic T lymphocytes [J].

Bergmann-Leitner, ES ;

Abrams, SI .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2001, 50 (09) :445-455

[3] 5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients [J].

Backus, HHJ ;

Dukers, DF ;

van Groeningen, CJ ;

Vos, W ;

Bloemena, E ;

Wouters, D ;

van Riel, JMGH ;

Smid, K ;

Giaccone, G ;

Pinedo, HM ;

Peters, GJ .

ANNALS OF ONCOLOGY, 2001, 12 (02) :209-216

[4]

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with?liver metastases from colorectal cancer[J] . H. H. J. Backus,J. M. G. H. van Riel,C. J. van Groeningen,W. Vos,D. F. Dukers,E. Bloemena,D. Wouters,H. M. Pinedo,G. J. Peters.Annals of Oncology . 2001 (6)

[5] 5-fluorouracil induces apoptosis through the suppression of NF-κB activity in human salivary gland cancer cells [J].

Aota, K ;

Azuma, M ;

Yamashita, T ;

Tamatani, T ;

Motegi, K ;

Ishimaru, N ;

Hayashi, Y ;

Sato, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (03) :1168-1174

[6]

Morphological change, loss of Δ ψ m and activation of caspases upon apoptosis of colorectal adenocarcinoma induced by 5-FU[J] . Kazuya Ikebukuro,Yasushi Adachi,Junko Toki,Shigeru Taketani,Rikio Tokunaga,Koshiro Hioki,Susumu Ikehara.Cancer Letters . 2000 (1)

[7] Bax overexpression enhances cytochrome c release from mitochondria and sensitizes KATOIII gastric cancer cells to chemotherapeutic agent-induced apoptosis [J].

Sawa, H ;

Kobayashi, T ;

Mukai, K ;

Zhang, W ;

Shiku, H .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2000, 16 (04) :745-749

[8]

Mechanisms Underlying Apoptosis Induced by Combination of 5-Fluorouracil and Interferon-γ[J] . Minori Koshiji,Yasushi Adachi,Shigeru Taketani,Kenji Takeuchi,Koshiro Hioki,Susumu Ikehara.Biochemical and Biophysical Research Communications . 1997 (2)

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