补阳还五汤增加脑缺血后血管生成素-1的表达及促进血管生成和神经功能改善(英文)

被引：30

作者：

Jian SHEN ^{[1
]}

Yu ZHU ^{[1
]}

Hai YU ^{[1
]}

Zuoxu FAN ^{[1
]}

Feng XIAO ^{[1
]}

Pan WU ^{[1
]}

Qihui ZHANG ^{[2
]}

Xiaoxing XIONG ^{[3
]}

Jianwei PAN ^{[1
]}

Renya ZHAN ^{[1
]}

机构：

[1] Brain Medicine Center, the First Affiliated Hospital, School of Medicine, Zhejiang University

[2] Dongfang Hospital, Beijing University of Chinese Medicine

[3] Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University

来源：

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) | 2014年 / 15卷 / 03期

关键词：

补阳还五汤; 血管生成素-1; 血管生成; 慢性脑损伤; 神经修复;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

研究目的:补阳还五汤对脑缺血后缺血区血管生成的影响及其机制。创新要点:研究结果表明补阳还五汤可能通过增加血管生成素-1的表达,促进缺血区血管新生,从而促进脑梗死后神经功能恢复。研究方法:通过神经功能评分、脑梗死及脑萎缩体积评估神经功能恢复情况;通过免疫组化及免疫印迹等方法检测血管密度及血管生成因子的表达情况。重要结论:补阳还五汤增加脑缺血后血管生成素-1的表达,能够促进脑梗死缺血区血管生成。

引用

页码：272 / 280

页数：9

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