Light-triggered molecule-scale drug dosing devices

被引：104

作者：

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom ^{[1
]}

机构：

[1] School of Pharmacy, Queen's University Belfast

来源：

J. Am. Chem. Soc. | 2007年 / 31卷 / 9572-9573期

关键词：

D O I：

10.1021/ja073053q

中图分类号：

学科分类号：

摘要：

We have synthesized a range of photolabile conjugates of 3,5-dimethoxybenzoin with acetyl salicylic acid, ibuprofen, and ketoprofen. These conjugates can be precisely kinetically controlled to liberate free drug following exposure to 365 nm light for defined periods. Incorporation of the conjugates into limited-porosity hydrogels, comprising a hydrated copolymer of 2-(hydroxyethyl) methacrylate and methyl methacrylate, crosslinked with ethylene glycol dimethacrylate, leads to dosing devices functional at the molecular level, which release precise doses of drug in response to applied light. A paradigm for the controlled, light-triggered release of stepped" doses of drugs from polymeric scaffolds is thus demonstrated. Copyright © 2007 American Chemical Society."

引用

页码：9572 / 9573

页数：1

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