Facile synthesis of 1,1-disubstituted taurines

被引：36

作者：

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China ^{[1
]}

机构：

[1] Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University

来源：

Synthesis | 2006年 / 2卷 / 315-319期

关键词：

Amino acid; Aminoalkanesulfonic acid; Episulfide; Epoxide; Ketone; Synthesis; Taurine;

D O I：

10.1016/j.ygeno.2005.11.011

中图分类号：

学科分类号：

摘要：

A series of 1,1 -disubstituted taurines was synthesized expeditiously from ketones via the Corey-Chaykovsky epoxidation with dimethylsulfonium methylide, episulfidation with potassium sulfocyanate, ring-opening reaction with ammonia in the presence of silver nitrate, followed by treatment with hydrogen sulfide and oxidation with performic acid. © Georg Thieme Verlag Stuttgart.

引用

页码：315 / 319

页数：4

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