Advanced control of crystallization processes

被引：225

作者：

Braatz, Richard D. ^{[1
]}

机构：

[1] University of Illinois at Urbana-Champaign, Box C-3, 600 South Mathews Avenue, Urbana, IL 61801, United States

来源：

Annual Reviews in Control | 2002年 / 26 I卷

关键词：

Algorithms - Chemical sensors - Computer simulation - Control system synthesis - Crystal structure - Crystallization - Dissolution - Drug products - Filtration - Identification (control systems) - Optimal control systems - Robustness (control systems);

D O I：

10.1016/S1367-5788(02)80016-5

中图分类号：

学科分类号：

摘要：

A key bottleneck in the production of pharmaceuticals and many other products is the formation of crystals from solution. The control of the crystal size distribution can be critically important for efficient downstream operations such as filtration and drying, and product effectiveness (e.g., bioavailability, tablet stability). This paper provides an overview of recent developments in the control of crystallization processes, including activities in sensor technologies, model identification, experimental design, process simulation, robustness analysis, and optimal control.

引用

页码：87 / 99