Improved characterisation of focal liver tumours: Dynamic power Doppler imaging using NC100100 echo-enhancer

被引：30

作者：

Ramnarine, K.V. ^{[1
]}

Kyriakopoulou, K. ^{[1
]}

Gordon, P. ^{[1
]}

McDicken, N.W. ^{[1
]}

McArdle, C.S. ^{[1
]}

Leen, E. ^{[1
]}

机构：

[1] Department of Medical Physics and Medical Engineering, University of Edinburgh, Edinburgh EH3 9YW, Royal Infirmary

[2] Department of Radiology, Glasgow Royal Infirmary, Glasgow

[3] Nycomed Amersham, Oslo

[4] Department of Surgery, University of Edinburgh, Edinburgh

来源：

European Journal of Ultrasound | 2000年 / 11卷 / 02期

关键词：

Blood supply; Contrast media; Liver neoplasm; Power Doppler studies; Quantitative ultrasonography; Ultrasound;

D O I：

10.1016/S0929-8266(00)00074-4

中图分类号：

学科分类号：

摘要：

Objective: To assess the vascularisation of focal hepatic tumours using NC100100, enhanced power Doppler imaging. Methods: Twenty-two patients with focal liver tumours (12 metastases and ten hemangiomas) were studied. Using standardised settings, power Doppler imaging with ATL HDI3000 was performed before and after intravenous administration of NC100100 contrast agent. The video-recorded examinations were digitised for off-line analysis on a personal computer. Regions of interest were defined over the entire tumour and a neighbouring area of the normal liver parenchyma. The temporal changes of the mean power Doppler signal intensity (PDSI) was quantified to provide contrast agent wash-in (PDSI-time) curves for the initial 40 s. Results: Liver metastases were characterised by a rapid increase in PDSI, while the PDSI-time curves within hemangiomas were flat. The PDSI within the tumour increased significantly in ten subjects with liver metastases and only one subject with hemangioma. An enhanced rim around hemangiomas was seen in four subjects. There was no clear relationship between the contrast agent dose and the peak PDSI within metastases. Conclusions: Power Doppler imaging with NC100100 contrast agent enhances tumour visualisation and may aid differential diagnosis of focal liver lesions. © 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：95 / 104

页数：9

共 23 条

[1]

Choi B.I., Kim T.K., Han J.K., Chung J.W., Park J.H., Han M.C., Power versus conventional colour Doppler sonography: Comparison in the depiction of vasculature in liver tumours, Radiology, 200, pp. 55-58, (1996)

[2]

Dock W., Grabenwoger F., Metz V., Eibenberger K., Farres M.T., Tumour vascularization assessment with Duplex sonography, Radiology, 181, pp. 241-244, (1991)

[3]

Ernst H., Hahn E.G., Balzer T., Schlief R., Heyder N., Colour doppler ultrasound of liver lesions: Signal enhancement after intravenous injection of the ultrasound contrast agent Levovist, J Clin Ultrasound, 24, pp. 31-35, (1996)

[4]

Goldberg B.B., Hilpert P.L., Burns P.N., Liuj B., Newman L.M., Merton D.A., Witlin L.A., Hepatic tumours: Signal enhancement at Doppler US after intravenous injection of a contrast agent, Radiology, 177, pp. 713-717, (1990)

[5]

Goldberg B.B., Merton D.A., Forsberg F., Liu J.B., Rawool N., Colour amplitude imaging: Preliminary results using vascular sonographic contrast agents, J Ultrasound Med, 15, pp. 127-134, (1996)

[6]

Hauff P., Fritzsch T., Reinhardt M., Weitschies W., Luders F., Uhlendorf V., Heldmann D., Delineation of experimental liver tumours in rabbits by a new ultrasound contrast agent and stimulated acoustic emission, Invest Radiol, 32, pp. 94-99, (1997)

[7]

Huisman H.J., Thijssen J.M., Wagener D.J.T., Rosenbusch G.J.E., Quantitative ultrasonic analysis of liver metastases, Ultrasound Med Biol, 24, pp. 67-77, (1998)

[8]

Kim A.Y., Choi B.I., Kim T.K., Et al., Hepatocellular carcinoma: Power Doppler US with a contrast agent - Preliminary results, Radiology, 209, pp. 135-140, (1998)

[9]

Leen E., Goldberg J.A., Robertson J., Sutherland G.R., Hemingway D.M., Cooke T.G., McArdle C.S., Detection of hepatic metastases using duplex color Doppler sonography, Ann Surg, 214, pp. 599-604, (1991)

[10]

Leveson S.H., Wiggins P.A., Giles G.R., Robinson P.J., Parkin, Dynamic hepatic perfusion scintigraphy for the detection of hepatic metastases, Br J Radiol, 56, pp. 988-989, (1983)

← 1 2 3 →