Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats

被引：164

作者：

Benedetti, L. ^{[1
]}

Cortivo, R. ^{[2
]}

Berti, T. ^{[2
]}

Berti, A. ^{[2
]}

Pea, F. ^{[2
]}

Mazzo, M. ^{[2
]}

Moras, M. ^{[3
]}

Abatangelo, G. ^{[2
]}

机构：

[1] Fidia Advanced Biopolymers, via Ponte delia Fabbrica, Abano Terme, Italy

[2] Institute of Histology and Embryology, University of Padova, 75 via Trieste, Padova, Italy

[3] Department of Pharmacology, University of Padova, Largo E. Meneghetti, Padova, Italy

来源：

Biomaterials | 1993年 / 14卷 / 15期

关键词：

Alcohols - Biocompatibility - Biodegradation - Chemical modification - Esterification - Implants (surgical) - Living systems studies - Physical properties - Physiological models;

D O I：

10.1016/0142-9612(93)90160-4

中图分类号：

学科分类号：

摘要：

Hyaluronan (HL), a naturally occurring glycosaminoglycan, has been chemically modified through the esterification of its carboxylic groups with different types of alcohol. The physico-chemical properties of these new biopolymers allow the preparation of many biomaterials which may be used in several medical applications. In the present study both the biocompatibility and biodegradation of some water-insoluble HL esters have been evaluated, either as raw material or as manufactured devices after subcutaneous and intraperitoneal implantation in male rats. The inflammatory response and the degree of resorption for each tested material are reported. The relationships between the degree of esterification and the type of alcohol used with the above parameters are also investigated.

引用

页码：1154 / 1160