过敏性紫癜研究进展

被引:16
作者
李作艳
王予川
机构
[1] 贵州省人民医院儿科
关键词
紫癜,过敏性; 病因; 发病机制; 治疗;
D O I
暂无
中图分类号
R725.5 [小儿血液及淋巴系疾病];
学科分类号
摘要
<正>过敏性紫癜(HSP)是儿童期常见的以坏死性小血管炎为主要病理改变的全身性疾病,可累及皮肤、关节、胃肠道、肾脏等全身器官。临床主要表现为紫癜、关节炎或关节痛、腹痛及蛋白尿、血尿等,大多具有自限性,但部分患者反复发作,迁延难愈,少数紫癜性肾炎可进展至肾功能衰竭导致死亡,或并发肠穿孔危及生命。目前HSP的病因及发病机制尚未完全明确,有学者认为各种病原体感染、遗传易感性是该病的主要病因…,而辅助性T细胞(Th1/Th2)免疫失衡、肿瘤坏死因子、白细胞介素(IL)、血管内皮生长因子等在HSP发病过程中起着重要作用。该病目前尚无统一的、完全有效的治疗方案.主要治疗用药为抗组胺药、糖皮质激素、免疫抑
引用
收藏
页码:764 / 768
页数:5
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