替格瑞洛在急性冠状动脉综合征中的临床应用

被引:9
作者
马志超 [1 ,2 ]
鲍晓雪 [3 ,2 ]
卢安 [1 ]
刘瑜 [1 ]
李明月 [1 ]
崔泽 [1 ]
机构
[1] 河北省疾病预防控制中心
[2] 河北医科大学研究生学院
[3] 河北医科大学附属第三医院内分泌二科
关键词
急性冠状动脉综合征; 替格瑞洛; 双联抗血小板疗法;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
摘要
<正>急性冠状动脉综合征(ACS)是指冠状动脉粥样硬化性心脏病(冠心病)患者粥样斑块破裂引起心肌缺血所致的一类疾病,包括不稳定型心绞痛(UA)、ST段抬高型心肌梗死(STEMI)和非ST段抬高型心肌梗死(NSTEMI)。不稳定斑块破裂后,血小板活化、聚集,血栓形成,最终导致心肌组织的供氧减少。由于血小板在动脉血栓形成的病理、生理过程
引用
收藏
页码:1726 / 1728
页数:3
相关论文
共 21 条
[1]   Ticagrelor: Pharmacokinetics, Pharmacodynamics, Clinical Efficacy, and Safety [J].
Dobesh, Paul P. ;
Oestreich, Julie H. .
PHARMACOTHERAPY, 2014, 34 (10) :1077-1090
[2]   Pharmacokinetic Interaction Study of Ticagrelor and Cyclosporine in Healthy Volunteers [J].
Teng, Renli ;
Kujacic, Mirjana ;
Hsia, Judith .
CLINICAL DRUG INVESTIGATION, 2014, 34 (08) :529-536
[3]   CYP2C19 Poor Metabolizer Is Associated With Clinical Outcome of Clopidogrel Therapy in Acute Myocardial Infarction But Not Stable Angina [J].
Kim, Ho-Sook ;
Chang, Kiyuk ;
Koh, Yoon-Seok ;
Park, Mahn-Won ;
Choi, Yun-Seok ;
Park, Chul-Soo ;
Oh, Minkyung ;
Kim, Eun-Young ;
Shon, Ji-Hong ;
Shin, Jae-Gook ;
Seung, Ki-Bae .
CIRCULATION-CARDIOVASCULAR GENETICS, 2013, 6 (05) :514-521
[4]   A pharmacokinetic interaction study of ticagrelor and digoxin in healthy volunteers [J].
Teng, Renli ;
Butler, Kathleen .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 69 (10) :1801-1808
[5]  
Variability of on-treatment platelet reactivity in patients on clopidogrel.[J].Matthias K. Freynhofer;Veronika Bruno;Ivan Brozovic;Rudolf Jarai;Birgit Vogel;Serdar Farhan;Wolfgang H&uuml;bl;Martin Willheim;Johann Wojta;Kurt Huber.Platelets.2013, 5
[6]   Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects [J].
Holmberg, Mikko T. ;
Tornio, Aleksi ;
Joutsi-Korhonen, Lotta ;
Neuvonen, Mikko ;
Neuvonen, Pertti J. ;
Lassila, Riitta ;
Niemi, Mikko ;
Backman, Janne T. .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2013, 75 (06) :1488-1496
[7]   Pharmacokinetics, Pharmacodynamics, and Safety of Ticagrelor in Volunteers With Severe Renal Impairment [J].
Butler, Kathleen ;
Teng, Renli .
JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 52 (09) :1388-1398
[8]  
2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update): A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.[J].Hani Jneid;Jeffrey L. Anderson;R. Scott Wright;Cynthia D. Adams;Charles R. Bridges;Donald E. Casey;Steven M. Ettinger;Francis M. Fesmire;Theodore G. Ganiats;A. Michael Lin
[9]  
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions.[J].Glenn N. Levine;Eric R. Bates;James C. Blankenship;Steven R. Bailey;John A. Bittl;Bojan Cercek;Charles E. Chambers;Stephen G. Ellis;Robert A. Guyton;Steven M. Hollenberg;Umesh N. Khot;Richard A. Lange;Laura Mauri;Roxana Mehran;Issam D. Moussa;
[10]  
Critical appraisal of ticagrelor in the management of acute coronary syndrome.[J].James Nawarskas;Snowden.Therapeutics and Clinical Risk Management.2011, defa