血清sTREM-1对脓毒症诊断及预后评估中的价值研究

被引:20
作者
刘雪燕
吴伟元
江意春
黄泽伟
袁丰华
徐勇
机构
[1] 深圳市人民医院暨南大学第二临床医学院
关键词
脓毒症; 可溶性髓样细胞触发受体-1(sTREM-1); 诊断; 预后;
D O I
暂无
中图分类号
R459.7 [急症、急救处理];
学科分类号
100231 [临床病理学];
摘要
目的 初步评价血清可溶性髓样细胞触发受体-1(sTREM-1)浓度对脓毒症患者诊断及预后判断的价值。方法收集深圳市人民医院重症医学科符合sepsis 3.0诊断标准的患者共84例,根据患者样本微生物培养结果分为微生物培养阳性组和阴性组,根据患者28 d时的生存情况分为死亡组和生存组,测量其入组后1 h血清sTREM-1水平,并进行多器官衰竭(SOFA)评分,记录相关的临床指标,分析sTREM-1表达及相关指标在不同分组中的差异,并用Logistic回归分析探讨与疾病死亡相关的危险因素。结果脓毒症患者血清sTREM-1的表达在生存组和死亡组之间差异有统计学意义(P<0.05)。ROC曲线分析发现,sTREM-1、APACHEⅡ评分和SOFA评分对预后均有一定的指导意义,其曲线下面积(AUC)分别为0.739、0.731和0.768。Logistic回归分析显示,血清sTREM-1水平是脓毒症患者的死亡独立危险因素。结论血清sTREM-1的表达量对脓毒症的预后评估有一定的指导作用。
引用
收藏
页码:1091 / 1095
页数:5
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