The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

被引：319

作者：

Agnes Klochendler‐Yeivin ^{[1
]}

Laurence Fiette ^{[2
]}

Jaqueline Barra ^{[3
]}

Christian Muchardt ^{[1
]}

Charles Babinet ^{[3
]}

Moshe Yaniv ^{[1
]}

机构：

[1] U.́ des Virus Oncogènes, CNRS URA 1644, Institut Pasteur, 75724 Paris Cedex 15

[2] Unité d'Histopathologie, Institut Pasteur, 75724 Paris Cedex 15

[3] U.́ de Biol. du Devmt., CNRS URA 1960, Institut Pasteur, 75724 Paris Cedex 15

来源：

The EMBO Reports | 2000年 / 1卷 / 6期

关键词：

D O I：

10.1093/embo-reports/kvd129

中图分类号：

学科分类号：

摘要：

The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as well as histone acetylation, were shown to facilitate gene activation. To investigate the function of two closely related mammalian SWI/SNF complexes in vivo, we inactivated the murine SNF5/INI1 gene, a common subunit of these two complexes. Mice lacking SNF5 protein stop developing at the peri-implantation stage, showing that the SWI/SNF complex is essential for early development and viability of early embryonic cells. Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild-type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types.

引用

页码：500 / 506

页数：6

共 31 条

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