Gender-dependent progression of systemic metabolic states in early childhood

被引：41

作者：

Janne Nikkilä ^{[1
]}

Marko Sysi‐Aho ^{[2
]}

Andrey Ermolov ^{[1
]}

Tuulikki Seppänen‐Laakso ^{[2
]}

Olli Simell ^{[3
]}

Samuel Kaski ^{[1
]}

Matej Orešič ^{[2
]}

机构：

[1] Department of Information and Computer Science, Helsinki Institute for Information Technology, Helsinki University of Technology, Espoo

[2] VTT Technical Research Centre of Finland, Espoo

[3] Department of Pediatrics, University of Turku, Turku

[4] Quantitative Biology and Bioinformatics, VTT Technical Research Centre of Finland, Espoo FI-02044 VTT

来源：

Molecular Systems Biology | / 4卷 / 1期

关键词：

Hidden Markov models; Lipid metabolism; Metabolomics; Multivariate longitudinal data; Pediatrics;

D O I：

10.1038/msb.2008.34

中图分类号：

学科分类号：

摘要：

Little is known about the human intra-individual metabolic profile changes over an extended period of time. Here, we introduce a novel concept suggesting that children even at a very young age can be categorized in terms of metabolic state as they advance in development. The hidden Markov models were used as a method for discovering the underlying progression in the metabolic state. We applied the methodology to study metabolic trajectories in children between birth and 4 years of age, based on a series of samples selected from a large birth cohort study. We found multiple previously unknown age- and gender-related metabolome changes of potential medical significance. Specifically, we found that the major developmental state differences between girls and boys are attributed to sphingolipids. In addition, we demonstrated the feasibility of state-based alignment of personal metabolic trajectories. We show that children have different development rates at the level of metabolome and thus the state-based approach may be advantageous when applying metabolome profiling in search of markers for subtle (patho)physiological changes. © 2008 EMBO and Nature Publishing Group.

引用

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