Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview

被引：4

作者：

Najm, Alfred ^{[1
,2
]}

Moldoveanu, Elena-Theodora ^{[3
]}

Niculescu, Adelina-Gabriela ^{[3
,4
]}

Grumezescu, Alexandru Mihai ^{[3
,4
]}

Beuran, Mircea ^{[1
,2
]}

Gaspar, Bogdan Severus ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Dept Surg, Bucharest 050474, Romania

[2] Emergency Hosp Floreasca Bucharest, Bucharest 014461, Romania

[3] Natl Univ Sci & Technol, Politehn Bucharest, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, Romania

[4] Univ Bucharest, Univ Bucharest ICUB, Romania Res Inst, Bucharest 050657, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 19期

关键词：

sarcopenia; drug delivery; treatment; muscles; aging of muscle; TESTOSTERONE REPLACEMENT; II RECEPTORS; DOUBLE-BLIND; MUSCLE; ANTIBODY; AGE; IDENTIFICATION; BIMAGRUMAB; INHIBITOR; SCAFFOLDS;

D O I：

10.3390/ijms251910766

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it is a public health problem that requires attention from researchers. This review aims to highlight drug delivery systems that have a high and efficient therapeutic potential for sarcopenia. Current as well as future research needs to consider the barriers encountered in the realization of delivery systems, such as the route of administration, the interaction of the systems with the aggressive environment of the human body, the efficient delivery and loading of the systems with therapeutic agents, and the targeted delivery of therapeutic agents into the muscle tissue without creating undesirable adverse effects. Thus, this paper sets the framework of existing drug delivery possibilities for the treatment of sarcopenia, serving as an inception point for future interdisciplinary studies.

引用

页数：34

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