IMPAIRED IGM ANTIBODY-RESPONSES TO AN INFLUENZA-VIRUS VACCINE IN ADULTS WITH SICKLE-CELL ANEMIA

被引：27

作者：

BALLESTER, OF

ABDALLAH, JM

PRASAD, AS

机构：

[1] WAYNE STATE UNIV, HARPER GRACE HOSP, SCH MED, DEPT MED, DETROIT, MI 48202 USA

[2] VET ADM MED CTR, ALLEN PK, MI 48101 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1985年 / 20卷 / 04期

关键词：

D O I：

10.1002/ajh.2830200413

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type-specific IgM and IgG antibody responses to a polyvalent influenza vaccine were evaluated in 16 adults with sickle cell anemia, with the use of an enzyme-linked immunosorbent assay. When compared to healthy controls, 8 out of the 16 patients had decreased or undetectable postvaccination anti-influenza IgM antibody levels. These patients were found to have significantly lower serum IgM levels and nondetectable splenic tissue (by 99Tc scans), as compared to those with normal IgM responses. Impaired IgM antibody primary immune responses may play a role in the pathogenesis of infectious complications seen in adult patients with sickle cell anemia.

引用

页码：409 / 412

页数：4

共 10 条

[1] POLYVALENT PNEUMOCOCCAL-POLYSACCHARIDE IMMUNIZATION OF PATIENTS WITH SICKLE-CELL-ANEMIA AND PATIENTS WITH SPLENECTOMY [J].