LEUKOTRIENE-D4 INCREASES NASAL BLOOD-FLOW IN HUMANS

被引：30

作者：

BISGAARD, H

OLSSON, P

BENDE, M

机构：

[1] CENT HOSP SKOVDE, SKOVDE, SWEDEN

[2] UNIV LUND HOSP, DEPT EAR NOSE & THROAT, S-22185 LUND, SWEDEN

[3] UNIV COPENHAGEN, BISPEBJERG HOSP, DEPT DERMATOL, DK-1168 COPENHAGEN, DENMARK

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1984年 / 27卷 / 04期

关键词：

D O I：

10.1016/0090-6980(84)90095-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of leukotriene D4 on the nasal mucosal blood flow in humans was measured using a laser doppler flow meter. The leukotriene solution was applied topically to the nasal mucosa in 9 healthy subjects, and changes in blood flow were measured non-traumatically by the laser doppler instrument. The response showed a consistent increase in blood flow. A dose-response was found in the range of 0.063-4.0 nmol. These results confirm an earlier study on the human skin, implicating leukotriene D4 as an important vasodilator in humans. No increase in nasal secretion was noted by the subjects tested.

引用

页码：599 / 604

页数：6

共 6 条

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[5] OLSSON P, UNPUB LASER DOPPLER
[6] LOCAL-EFFECTS OF SYNTHETIC LEUKOTRIENES (LTC4, LTD4, LTE4, AND LTB4) IN HUMAN-SKIN
SOTER, NA
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[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1983, 80 (02) : 115 - 119

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