BETA-ENDORPHIN IN THE HUMAN-PANCREAS

被引：248

作者：

BRUNI, JF

WATKINS, WB

YEN, SSC

机构：

[1] Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 49卷 / 04期

关键词：

D O I：

10.1210/jcem-49-4-649

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using a specific antiserum, .beta.-endorphin was quantitated in 8 human pancreas obtained at autopsy by radioimmunoassay and localized by immunocytochemistry. The mean (.+-. SE) concentration of .beta.-endorphin in pancreatic extracts of 5 non-diabetic adults was 13.5 .+-. 9.8 ng/gm with a range of 2.1-52.8 ng/gm of tissue. Pancreatic .beta.-endorphin concentration in 2 premature infants were within the range found in adults. In 1 diabetic pancreas, there was no measurable .beta.-endorphin. Specific .beta.-endorphin immunofluorescence is localized within the pancreatic islets. .beta.-Endorphin may participate in intraislet regulation of pancreatic hormone secretion.

引用

收藏

页码：649 / 651

页数：3

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