用抗病毒免疫核糖核酸诱生细胞毒因子的研究

被引：5

作者：

杨明久

赫甡

刘北星

机构：

[1] 中国医科大学免疫研究室沈阳

来源：

中华微生物学和免疫学杂志 | 1990年 / 10卷 / 04期

关键词：

抗病毒免疫核糖核酸; 呼吸道合胞病毒i-RNA; 巨细胞病毒i-RNA; 兔血清细胞毒因子;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

用抗呼吸道合胞病毒和巨细胞病毒的免疫核糖核酸(RSV i-RNA、CMV i-RNA), 分别对家兔进行连续致敏注射(ip)和诱生注射(iv), 能在家兔血清中诱生出杀伤靶细胞(L929细胞)活性较强的细胞毒因子(兔血清细胞毒因子:RSCF)。实验结果表明, 以正常的HeLa细胞或Hep-2细胞为靶细胞时, 它们对RSCF的作用都不敏感。但二种抗不同病毒i-RNA诱生的RSCF对被RSV感染的HeLa和Hep-2细胞的杀伤作用都非常明显, 而无特异性。文中对RSV i-RNA的抗感染作用和抗病毒i-RNA所诱生的RSCF活性组成作了讨论。

引用

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