IL-4对IL-2诱导LAK细胞和激活肿瘤浸润性淋巴细胞抗肿瘤活性的影响

被引：1

作者：

曹雪涛

叶天星

杨嗣坤

徐志工

孔宪涛

机构：

[1] 第二军医大学免疫学教研室上海

来源：

中华微生物学和免疫学杂志 | 1990年 / 10卷 / 05期

关键词：

白细胞介素4; 白细胞介素2; 淋巴因子激活的杀伤细胞; 肿瘤浸润性淋巴细胞; 抗肿瘤免疫;

D O I：

暂无

中图分类号：

R730.51 [免疫疗法];

学科分类号：

摘要：

为了提高肿瘤过继免疫疗法的抗肿瘤效果, 本研究试图应用白细胞介素4 (IL-4)提高具有显著抗肿瘤作用的免疫效应细胞(LAK和TIL)的体外杀伤活性, 结果表明, IL-4单独并不能诱导出LAK活性, IL-4对LAK细胞的抗肿瘤活性呈剂量依赖性地抑制作用, 抗IL- 4单抗(11B11)能完全阻断IL-4对LAK活性的抑制作用。但IL-4能够进一步增强IL-2激活的TIL的抗肿瘤活性, 这对于肿瘤的免疫治疗有很大的实用价值。文中对IL-4的作用机理进行了探讨。

引用

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